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044437 16-epi-Latrunculin B CAS: 444911-05-1

Specifications
References
CAS Number
444911-05-1
Grade
Highly Purified
Molecular Formula
C20H29NO5S
Molecular Weight
395.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Antiviral (against herpes simplex type 1 virus (HSV-1)). Cytotoxic. Depolymerizes actin filaments (F-actin).

CAS Number
444911-05-1
Source
Marine sponge Negombata magnifica.
Molecular Weight
395.5
Molecular Formula
C20H29NO5S
Solubility
DMSO or ethanol
Appearance
Supplied as a white to off-white solid.
Purity
≥98% (HPLC)
Storage and Stability
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
Product Reference: |●Toward computing relative configurations: 16-epi-latrunculin B, a new stereoisomer of the actin polymerization inhibitor latrunculin B: T.R. Hoye, et al.; JACS 124, 7405 (2002) Abstract|●A new dimension to the biosynthetic products isolated from the sponge Negombata magnifica: B. Vilozny, et al.; J. Nat. Prod. 67, 1055 (2004)|●Diverted total synthesis: Preparation of a focused library of latrunculin analogues and evaluation of their actin-binding properties: A. Fürstner, et al.; PNAS 102, 8103 (2005)|●Total syntheses of the actin-binding macrolides latrunculin A, B, C, M, S and 16-epi-latrunculin B: A. Fürstner, et al.; Chemistry 13, 115 (2007)|●Interrogating the Bioactive Pharmacophore of the Latrunculin Chemotype by Investigating the Metabolites of Two Taxonomically Unrelated Sponges: T. Amagata, et al.; J. Med. Chem. 51, 7234 (2008)|●
USBio References
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