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044600 Bilobalide CAS: 33570-04-6

Specifications
References
CAS Number
33570-04-6
Grade
Highly Purified
MDL Number
MFCD00238547
Molecular Formula
C15H18O8
Molecular Weight
326.3
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C/-20°C

Neuroprotective. Mitochondrial gene expression regulator. ROS scavenger. Competitive GABA(A) receptor antagonist. Apoptosis inhibitor. CREB phosphorylation enhancer. Stimulates neurogenesis and synaptogenesis. Hepatic cytochrome P450 inducer. Activates the phosphatidylinositol 3-kinase (PI3K) dependent pathway.

CAS Number
33570-04-6
Source
Ginko biloba
Molecular Weight
326.3
Molecular Formula
C15H18O8
Solubility
Ethanol or DMSO
Appearance
Supplied as a white solid.
Purity
≥95% (1H-NMR)
Storage and Stability
Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
Product Reference: |●Bilobalid A, ein neues Sesquiterpen mit tert.-Butyl-Gruppe aus den Blättern von Ginkgo biloba L.: K. Weinges & W. Bähr; Liebigs Ann. Chem. 724, 214 (1969)|●Protection of hypoxia-induced ATP decrease in endothelial cells by ginkgo biloba extract and bilobalide: D. Janssens, et al.; Biochem. Pharmacol. 50, 991 (1995)|●Protection of mitochondrial respiration activity by bilobalide: D. Janssens, et al.; Biochem. Pharmacol. 58, 109 (1999)|●Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide: L.J. Zhou & X.Z. Zhu; J. Pharmacol. Exp. Ther. 293, 982 (2000)|●Bilobalide and neuroprotection: F.V. Defeudis; Pharmacol. Res. 46, 565 (2002) (Review)|●Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors: S.H. Huang, et al.; Eur. J. Pharmacol. 464, 1 (2003)|●Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death: K. Chandrasekaran, et al.; Pharmacopsychiatry 36 Suppl 1, S89 (2003)|●Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons: F. Tchantchou, et al.; J. Alzheimers Dis. 18, 787 (2009)|●Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats: Y. Taki, et al.; J. Pharmacol. Sci. 109, 459 (2009)|●Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells: C. Shi, et al.; Apoptosis 15, 715 (2010)|●Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway: C. Shi, et al.; Neurochem. Int. 59, 59 (2011)
USBio References
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