TRPM-2, Apolipoprotein J, APO-J, CLI, CLU, SGP-2
Clusterin is a secretory heterodimeric disulfide-linked glycoprotein that is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation.
Signal peptide sequence and the human secretory clusterin (aa1-449) are fused at the C-terminus to a FLAG®-tag, expressed in HEK293 cells.
Molecular Weight
~80kD (under non-reducing conditions); 39kD and 40kD (under reducing conditions) (SDS-PAGE).
Storage and Stability
Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, HEK293 cells
Form
Supplied as a lyophilized powder in PBS. Reconstitute with sterile ddH2O. PBS with at least 0.1% BSA should be used for further dilutions
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
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