Delta-like Protein 1, Delta 1
The Notch ligand delta-like protein 1 (DLL1) is essential for postnatal arteriogenesis and contributes to tumor progression. DLL1 is involved in differentiation and self-renewal of adipocyte stem cells. Blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T cell/NK-cell precursor.
Recombinant protein corresponding to the signal peptide and extracellular domain of mouse DLL1 (aa1-545) fused at the C-terminus to the Fc portion of human IgG1, expressed in HEK293 cells. Swiss/UniProt Accession: Q61483
Biological Activity
Inhibits adipogenesis of 3T3L-1 cells. Induces Hes-1 in 3T3L-1 cells.
Specificity
Interacts with Notch receptors
Storage and Stability
Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, HEK293 cells
Form
Supplied as a lyophilized powder from PBS. Reconstitute with 50ul or 100ul sterile ddH2O
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
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