Tumor Necrosis Factor Receptor Superfamily Member 18, Activation-inducible TNFR Family Receptor, Glucocorticoid-induced TNFR-related Protein, CD357, TNFRSF18, AITR
GITR (Glucocorticoid-induced TNF receptor) is the receptor for TNFSF18. It is involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T cell receptor-mediated cell death. GITR serves as a negative regulator for NK cell activation. It mediates NF-kappaB activation via the TRAF2/NIK pathway.
Sequence
Mouse GITR (aa 20-152) is fused at the C-terminus to the Fc portion of human IgG1.
Storage and Stability
Short-term Storage: +4°C Long-term Storage: -20°C Stable for at least 6 months after receipt when stored at -20°C.
Source
Human, Mouse, HEK 293 cells
Form
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
Specificity
Binds to mouse GITRL.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.