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044874 GW1929 CAS: 196808-24-9

Specifications
References
CAS Number
196808-24-9
Grade
Highly Purified
Molecular Formula
C30H29N3O4
Molecular Weight
495.6
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C/-20°C
N-(2-Benzoylphenyl)-L-tyrosine PPARγ Agonist; (2S)-((2-Benzoylphenyl)amino-3-[4-[2-(methylpyridin-2-ylamino)ethoxy]phenyl]propionic acid

Potent and subtype-selective (>1000-fold) PPARgamma agonist. Angiogenesis and apoptosis inhibitor. Anti-inflammatory. Anti-hyperglycemic and anti-hyperlipidemic agent. GW1929 is an antidiabetic; the glucose-lowering effect in rats is 100-fold more potent than that of troglitazone.

Synonyms
N-(2-Benzoylphenyl)-L-tyrosine PPARγ Agonist; (2S)-((2-Benzoylphenyl)amino-3-[4-[2-(methylpyridin-2-ylamino)ethoxy]phenyl]propionic acid
CAS Number
196808-24-9
Molecular Weight
495.6
Molecular Formula
C30H29N3O4
Solubility
DMSO or methanol
Appearance
Supplied as an off-white to yellow crystalline solid.
Purity
≥98% (NMR)
Storage and Stability
May be stored at 4°C for short-term only. Protect from light. Stable for 12 months after receipt when stored at -20°C. Store solutions at -20°C in the dark. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents: B.R. Henke, et al.; J. Med. Chem. 41, 5020 (1998)|2. A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat: K.K. Brown, et al.; Diabetes 48, 1415 (1999)|3. PPARgamma agonists inhibit angiogenesis by suppressing PKCalpha- and CREB-mediated COX-2 expression in the human endothelium: E. Scoditti, et al.; Cardiovasc. Res. 86, 302 (2010)|4. Ameliorative Effects of GW1929, a Nonthiazolidinedione PPAR gamma Agonist, on Inflammation and Apoptosis in Focal Cerebral Ischemic-Reperfusion Injury: R.K. Kaundal & S.S. Sharma; Curr. Neurovasc. Res. 8, 236 (2011)
USBio References
No references available
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