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044993 LAG-3,Fc, Recombinant, Human (Lymphocyte Activation Gene-3, FDC Protein, CD223) CAS:

Specifications
References
Grade
Highly Purified
Swiss Prot
P18627
Molecular Weight
80
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
-20°C
Lymphocyte Activation Gene-3, FDC Protein, CD223

Lymphocyte activation gene 3 (LAG-3) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

Sequence
The sequence coding for the 4 extracellular Ig-like domains of human LAG-3 (D1-D4) is fused to the Fc portion of human IgG1.
Endotoxin (LAL)
≤0.1EU/ug
Biological Activity
Inhibits binding of MAb to LAG-3 (human) to LAG-3. Induces maturation of human dendritic cells.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, CHO cells
Purity
≥99% (SDS-PAGE)
Concentration
~0.5mg/ml
Form
Supplied as a liquid in PBS.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Huard, B., et al., Eur. J. Immunol. 25: 2718 (1995). 2. Huard, B., et al., Eur. J. Immunol. 26: 1180 (1996). 3. Andreae, S., et al., J. Immunol. 168: 3874 (2002). 4. Buisson, S. & Triebel, F., Immunology 114: 369 (2005). 5. Triebel, F., et al., Cancer Lett. 235: 147 (2006). 6. Brignone, C., et al., J. Immunol. 179: 4202 (2007).
USBio References
No references available
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