MnTBAP chloride CAS 55266-18-7

CAS Number

55266-18-7

Grade

Highly Purified

Molecular Formula

C48H28MnN4O8Cl

Molecular Weight

879.2

EU Commodity Code

38220090

Shipping Temp

Storage Temp

4°C/-20°C

Manganese (III) tetrakis (4-benzoic acid)porphyrin chloride

Cell permeable superoxide dismutase (SOD) mimetic. Potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO). Neuronal apoptosis inhibitor. Protects T cells from superoxide generation, caspase-dependent DNA loss and cell death. Lipopolysaccharide-induced TNF-alpha production inhibitor, by prevention of intracellular ROS generation and subsequent inactivation of p38 MAPK and SAPK/JNK.

Synonyms

Manganese (III) tetrakis (4-benzoic acid)porphyrin chloride

CAS No

55266-18-7

Molecular Weight

879.2

Molecular Formula

C48H28MnN4O8Cl

Solubility

Dissolve at 0.1M in aqueous base, then add buffer to lower pH to pH 7.0 or higher as needed.

Appearance

Supplied as a black crystalline powder.

Purity

≥97%

Storage and Stability

For short term storage, store at 4°C. Stable for 12 months after receipt when stored at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards

All products should be handled by qualified personnel only, trained in laboratory procedures.

References

1. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo: K.M. Faulkner, et al.; J. Biol. Chem. 269, 23471 (1994)|2. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro: B.J. Day, et al.; J. Pharm. Exp. Ther. 275,1227 (1995)|3. Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger: C. Szabó, et al.; FEBS Lett. 381, 82 (1996)|4. Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic: M. Patel; J. Neurochem. 71, 1068 (1998)|5. Reactive oxygen species regulate activation-induced T cell apoptosis: D.A. Hildeman, et al.; Immunity 10, 735 (1999)|6. MnTBAP, a synthetic metalloporphyrin, inhibits production of tumor necrosis factor-alpha in lipopolysaccharide-stimulated RAW 264.7 macrophages cells via inhibiting oxidative stress-mediating p38 and SAPK/JNK signaling: G. Tumurkhuu, et al.; FEMS Immunol. Med. Microbiol. 49, 304 (2007)

USBio References

No references available

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045036 MnTBAP chloride CAS: 55266-18-7

CAS Number

Grade

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

Manganese (III) tetrakis (4-benzoic acid)porphyrin chloride

References

USBio References

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