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045078 Netrin-1,Fc, Recombinant, Human (NTN1) CAS:

Specifications
References
Grade
Highly Purified
Specificity
Binds to human, mouse and rat UNC5B.
Molecular Weight
90
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
4°C/-20°C
NTN1

Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin 1 is also Involved in tumorigenesis by regulating apoptosis.

Biological Activity
Induces axon outgrowth.
Sequence
Human netrin-1 (aa 25-604) is fused at the C-terminus to the Fc portion of human IgG1.
Storage and Stability
Short-term Storage: +4°C Long-term Storage: -20°C Stable for at least 6 months after receipt when stored at -20°C.
Source
Recombinant, HEK293 cells
Purity
>95% (SDS-PAGE)
Concentration
0.1mg/ml
Form
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2, with trehalose and Brij35.
Specificity
Binds to human, mouse and rat UNC5B.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
Product Reference: |●DCC constrains tumour progression via its dependence receptor activity: M. Castets, et al.; Nature 482, 534 (2011)|●
USBio References
No references available
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