TRANCE-R, TNFRSF11A, ODFR, Osteoclast Differentiation Factor Receptor, CD265
RANK (TRANCE-R; CD265) is the receptor for RANKL/TRANCE/OPGL. It is essential for RANKL-mediated osteoclastogenesis and is involved in the regulation of interactions between T cells and dendritic cells.
Human RANK (aa 29-213) is fused at the C-terminus to the Fc portion of human IgG1.
Biological Activity
Inhibits human rhsRANKL biological functions.
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, HEK293 cells
Concentration
~1mg/ml (after reconstitution)
Form
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2. Reconstitute with 50ul of sterile ddH2O.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.