SANT-2 CAS 329196-48-7

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045270 SANT-2 (N-3,4,5-triethoxybenzamide) CAS: 329196-48-7

Specifications

References

CAS Number

329196-48-7

Grade

Highly Purified

Molecular Formula

C26H26ClN3O4

Molecular Weight

480

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

4°C/-20°C

N--3,4,5-triethoxybenzamide

Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo. Tool to study hedgehog (Hh) signaling pathway. SAG activity inhibitor. Gli1 reporter gene expression inhibitor. Suppresses the Shh-dependent translocation of Smo to the primary cilium. Potential tumor growth blocker.

Synonyms

N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide

CAS Number

329196-48-7

Molecular Formula

C26H26ClN3O4

Molecular Weight

480

Solubility

DMSO, ethanol or chloroform.

Appearance

Supplied as a white to off-white solid.

Purity

≥95% (NMR)

Storage and Stability

Store at 4°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

References

Product Reference: |●Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS 99, 14071 (2002)|●Targeting the Hedgehog pathway in cancer: L.L. Rubin & F.J. de Sauvage; Nat. Rev. Drug. Discov. 5, 1026 (2006) (Review)|●Evidence for allosteric interactions of antagonist binding to the smoothened receptor: C.M. Rominger, et al.; J. Pharmacol. Exp. Ther. 329, 995 (2009)|●Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process: R. Rohatgi, et al.; PNAS 106, 3196 (2009)|●Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway: A. Büttner, et al.; Bioorg. Med. Chem. 17, 4943 (2009)|●