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045336 Thiocolchicoside CAS: 602-41-5

Specifications
References
CAS Number
602-41-5
Grade
Highly Purified
MDL Number
MFCD07995056
Molecular Formula
C27H33NO10S
Molecular Weight
563.6
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C/-20°C
BRN 0072205, NSC 147755, Coltramyl, 10-thio-Colchicoside, 2-Demethoxy-2-glucosidoxythiocolchicine

Potent competitive gamma-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist. Weak nicotinic acetylcholine receptor agonist. Muscle relaxant. Anti-inflammatory. Has analgesic properties. Shows strong epileptogenic and convulsant activity. Anticancer compound through inhibition of NF-kappaB and NF-kappaB-regulated gene products. Apoptosis inducer. Suppressed osteoclastogenesis induced by RANKL and tumor cells via the NF-kappaB signaling pathway. Therapeutic option for the management of bone metastatic disease.

Synonyms
BRN 0072205; NSC 147755; Coltramyl; 10-thio-Colchicoside; 2-Demethoxy-2-glucosidoxythiocolchicine
CAS Number
602-41-5
Source
Semi-synthetic
Molecular Weight
563.6
Molecular Formula
C27H33NO10S
Solubility
Water or ethanol.
Appearance
Supplied as a yellow solid.
Purity
≥95% (NMR)
Storage and Stability
Store at 4°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
Product Reference: |●Affinity of thiocolchicoside and thiocolchicoside analogues for the postsynaptic GABA receptor site: K. Biziere, et al.; Eur. J. Pharmacol. 75, 167 (1981)|●Review of the toxicology, pharmacodynamics and pharmacokineticss of thiocolchicoside, a GABA-agonist muscle relaxant with anti-inflammatory and analgesic actions: J.M. Janbroers; Acta Ther. 13, 221 (1987)|●Interaction of thiocolchicoside with [3H]strychnine binding sites in rat spinal cord and brainstem: M. Cimino, et al.; Eur. J. Pharmacol. 318, 201 (1996)|●Focal and secondarily generalised convulsive status epilepticus induced by thiocolchicoside in the rat: G. Sechi, et al.; Seizure 12, 508 (2003)|●Multicenter, randomized, double-blinded, placebo-controlled trial of thiocolchicoside in acute low back pain: F. Tüzün, et al.; Joint Bone Spine 70, 356 (2003)|●The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system: M. Carta, et al.; Neuropharmacology 51, 805 (2006)|●Thiocolchicoside inhibits the activity of various subtypes of recombinant GABA(A) receptors expressed in Xenopus laevis oocytes: M.P. Mascia, et al.; Eur. J. Pharmacol. 558, 37 (2007)|●Thiocolchicoside exhibits anticancer effects through downregulation of NF-kappaB pathway and its regulated gene products linked to inflammation and cancer: S. Reuter, et al.; Cancer Prev. Res. 3, 1462 (2010)|●Thiocolchicoside suppresses osteoclastogenesis induced by RANKL and cancer cells through inhibition of inflammatory pathways: a new use for an old drug: S. Reuter, et al.; Br. J. Pharmacol. 165, 2127 (2012)|●Thiocolchicoside a semi-synthetic derivative of the Glory Lily: a new weapon to fight metastatic bone resorption? O. Micheau, et al.; Br. J. Pharmacol. 165, 2124 (2012)|●
USBio References
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