USBio Logo

045396 YC-1 CAS: 170632-47-0

Specifications
References
CAS Number
170632-47-0
Grade
Highly Purified
MDL Number
MFCD06407798
Molecular Formula
C₁₉H₁₆N₂O₂
Molecular Weight
304.4
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
1-Benzyl-3-(5-hydroxymethylfur-2-yl)indazole; Lificiguat, 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole

Nitric oxide (NO) independent, superoxide-sensitive soluble guanylyl cyclase (sGC) activator. Induces concentration-dependent increase in cGMP levels. Inhibits platelet adhesion to collagen. Thombosis inhibitor. Non-specific phosphodiesterase inhibitor. Na+ channel blocker. Anticancer compound. HIF-alpha inhibitor. Blocks angiogenesis. Tumor growth inhibitor. Apoptosis inducer. NK cell differentiation enhancer.

Synonyms
1-Benzyl-3-(5-hydroxymethylfur-2-yl)indazole; Lificiguat, 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole
CAS Number
170632-47-0
Molecular Weight
304.4
Molecular Formula
C₁₉H₁₆N₂O₂
Method for Determining Identity
Proton NMR
Appearance
White to pale yellow powder
Purity
≥98% (NMR)
Solubility
DMSO, methanol or dichloromethane
Storage and Stability
Store at 4°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
1. YC-1, a novel activator of platelet guanylate cyclase: F.N. Ko, et al.; Blood 84: 4226 (1994). 2. YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase: C.C. Wu, et al.; Br. J. Pharmacol. 116: 1973 (1995). 3. YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits platelet-rich thrombosis in mice: C.M. Teng, et al.; Eur. J. Pharmacol. 320: 161 (1997). 4. Mechanism of YC-1-induced activation of soluble guanylyl cyclase: A. Friebe & D. Koesling; Mol. Pharmacol. 53: 123 (1998). 5. BAY 41-2272 activates two isoforms of nitric oxide-sensitive guanylyl cyclase: M. Koglin, et al.; BBRC 292: 1057 (2002). 6. Soluble guanylyl cyclase activator YC-1 protects white matter axons from nitric oxide toxicity and metabolic stress, probably through Na(+) channel inhibition: G. Garthwaite, et al.; Mol. Pharmacol. 61: 97 (2002). 7. YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1: E.J. Yeo, et al.; J. Natl. Cancer Inst. 95: 516 (2003). 8. Versatile pharmacological actions of YC-1: anti-platelet to anticancer: Y.S. Chun, et al.; Cancer Lett. 207: 1 (2004) (Review). 9. A Novel Drug Binding Site on Voltage-Gated Sodium Channels in Rat Brain: D. R. Riddall, et al.; Mol. Pharmacol. 69: 278 (2006). 10. Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading: D.H. Shin, et al.; Cancer Lett. 255: 107 (2007). 11. YC-1 induces apoptosis of human renal carcinoma A498 cells in vitro and in vivo through activation of the JNK pathway: S.Y. Wu, et al.; Br. J. Pharmacol. 155: 505 (2008). 12. YC-1 enhances natural killer cell differentiation from hematopoietic stem cells: S. Yun, et al.; Int. Im- munopharmacol. 10: 481 (2010). 13. Novel HTS strategy identifies TRAIL-sensitizing compounds acting specifically through the caspase-8 apop- totic axis: D. Finlay, et al.; PLoS One 5: e13375 (2010)
USBio References
No references available
Pricing
Order
Proceed to Checkout
Cart Summary
ProductSizeListYour PriceQtyExt Price
Subtotal:Subtotal:
Subtotal:Subtotal:
Total Coupon Savings:Total Coupon Savings:()
Your cart is currently empty.
- Coupon Code
Recently Viewed
  • Contact Us

    Visit our technical library or contact our support staff to answer your questions.

    Telephone:
    1-800-520-3011

    Library | Contact

    Distributors

    For customers outside of the United States, please use one of our many distributors.

    View Distributors

    Payment Methods

    We accept the following payment methods as well as pay-by-invoice.

    MasterCard Visa PayPal
    © 2023-2024 United States Biological - All Rights Reserved