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045400 Zerumbone CAS: 471-05-6

Specifications
References
CAS Number
471-05-6
Grade
Highly Purified
MDL Number
MFCD03700769
Molecular Formula
C15H22O
Molecular Weight
218.3
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C/-20°C
(2E,6E,10E)-2,6,9,9-Tetramethylcycloundeca-2,6,10-trien-1-one

Chemopreventive probe. Apoptosis inducer. Potent anti-tumor compound. Anti-inflammatory activity by downregulating COX-2 and iNOS expression via modulation of NF-kappaB activation. Antinociceptive. Probe to study chemokine receptors functioning. Potential therapeutic agent for osteoporosis and cancer-associated bone loss.

Synonyms
(2E,6E,10E)-2,6,9,9-Tetramethylcycloundeca-2,6,10-trien-1-one
CAS Number
471-05-6
Source
Underground parts of Curcuma zerumbet.
Molecular Weight
218.3
Molecular Formula
C15H22O
Solubility
DMSO or 100% ethanol
Use
For preparation of 1mM stock solution dissolve 0.218mg zerumbone in 1ml solvent.
Appearance
Supplied as solid white crystals or powder.
Purity
≥98% (HPLC)
Storage and Stability
Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
Product Reference: |●Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet: T. Tanaka, et al.; Life Sci. 69, 1935 (2001)|●Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species. S. Yodkeeree, et al.; Cancer Res. 69, 6581 (2009) |●Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells: S.I. Abdelwahab, et al.; Leuk. Res. Epub ahead of print (2010)|●Antitumor effects of zerumbone from Zingiber zerumbet in P-388D1 cells in vitro and in vivo: G.C. Huang, et al.; Planta Med. 71, 219 (2005)|●Zerumbone, an anti-inflammatory phytochemical, induces expression of proinflammatory cytokine genes in human colon adenocarcinoma cell lines: A. Murakami, et al.; Biofactors 21, 95 (2004)|●Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice: M. R. Sulaiman, et al.; Fitoterapia 81, 855 (2010)|●Preliminary analysis of the antinociceptive activity of zerumbone: M. R. Sulaiman, et al.; Fitoterapia 80, 230 (2009)|●Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells: B. Sung, et al.; Cancer Res. 68, 8938 (2008)|●Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice: B. Sung, et al.; Cancer Res. 69, 1477 (2009)|●Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion: Y. Takada, et al.; Oncogene 24, 6957 (2005)
USBio References
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