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045410 BLOC1S2, Recombinant, Human, aa1-142, His-Tag (Biogenesis of Lysosome-related Organelles Complex 1 Subunit 2, BLOC-1 Subunit 2, Centrosome-associated Protein, BLOS2, CEAP) CAS:

Specifications
References
Grade
Purified
Swiss Prot
Q6QNY1
Accession Number
NP_776170
Molecular Weight
18.5
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
-20°C

BLOC1S2 (Biogenesis of lysosome-related organelles complex 1 subunit 2) belongs to the BLOC1S2 family. BLOC-1 or biogenesis of lysosome-related organelles complex 1 is a ubiquitously expressed multisubunit protein complex. BLOC-1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. This protein plays a role in cell proliferation.

Recombinant corresponding to aa1-142 from human BLOC1S2, fused to His-tag at N-terminus, expressed in E. coli.
Molecular Weight
~18.5kD (166aa) confirmed by MALDI-TOF
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMAAAAE GVLATRSDEP ARDDAAVETA EEAKEPAEAD ITELCRDMFS KMATYLTGEL TATSEDYKLL ENMNKLTSLK YLEMKDIAIN ISRNLKDLNQ KYAGLQPYLD QINVIEEQVA ALEQAAYKLD AYSKKLEAKY KKLEKR
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, E. coli
Purity
≥85% (SDS-PAGE)
Concentration
~1mg/ml
Form
Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 1mM DTT, 50mM sodium chloride, 10% glycerol.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Starcevic M., et al. (2004) J. Biol. Chem. 279:28393-28401. 2. Wang Z., et al. (2004) J. Mol. Biol. 343:71-82.
USBio References
No references available
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