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045441 MAGEA6, Recombinant, Human, aa1-314, His-Tag (Melanoma-associated Antigen 6, Cancer/Testis Antigen 1.6, CT1.6, MAGE-6 Antigen, MAGE3B Antigen, MAGE6) CAS:

Specifications
References
Grade
Highly Purified
Molecular Weight
35.9
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
-20°C

MAGEA6 is a member of the MAGEA family, which directs the expression of tumor antigens that are recognized on a human melanoma by autologous cytolytic T lymphocytes (CTL). The MAGE genes were initially isolated from different kinds of tumors, and based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy.

Source
Recombinant corresponding to aa1-314 from human MAGEA6, fused to His-tag at N-terminus, expressed in E.coli.
Molecular Weight
~35.9kD (322aa) confirmed by MALDI-TOF
AA Sequence
MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQEAAS SSSTLVEVTL GEVPAAESPD PPQSPQGASS LPTTMNYPLW SQSYEDSSNQ EEEGPSTFPD LESEFQAALS RKVAKLVHFL LLKYRAREPV TKAEMLGSVV GNWQYFFPVI FSKASDSLQL VFGIELMEVD PIGHVYIFAT CLGLSYDGLL GDNQIMPKTG FLIIILAIIA KEGDCAPEEK IWEELSVLEV FEGREDSIFG DPKKLLTQYF VQENYLEYRQ VPGSDPACYE FLWGPRALIE TSYVKVLHHM VKISGGPRIS YPLLHEWALR EGEELEHHHH HH
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, E. coli
Purity
~90% (SDS-PAGE)
Concentration
~1mg/ml
Form
Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 1mM DTT, 0.1M sodium chloride, 10% glycerol.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Kobayasshi Y., et al. (2000) J Hepatol. 32:612-617. Klein C., et al. (2000) J Exp Med. 191: 1699-1708.
USBio References
No references available
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