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045464 STX12, Recombinant, Human, aa1-248, His-Tag (Syntaxin-12, Syntaxin 12) CAS:

Specifications
References
Grade
Highly Purified
Molecular Weight
31
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
-20°C

Syntaxin 12, also known as, belongs to the syntaxin family. Syntaxin family is cellular receptors for transport vesicles which participate in exocytosis in neutrophils. STX12 regulates protein transport between late endosomes and the trans-Golgi network and interacts with ABC1 (ATP-binding cassette transporter A1), a protein that facilitates cellular release of choline-phospholipids and cholesterol to apoA-I (apolipoprotein A-I).

Source
Recombinant corresponding to aa1-248 from human STX12, fused to His-tag at N-terminus, expressed in E.coli.
Molecular Weight
~31kD (272aa) confirmed by MALDI-TOF
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMSYGPL DMYRNPGPSG PQLRDFSSII QTCSGNIQRI SQATAQIKNL MSQLGTKQDS SKLQENLQQL QHSTNQLAKE TNELLKELGS LPLPLSTSEQ RQQRLQKERL MNDFSAALNN FQAVQRRVSE KEKESIARAR AGSRLSAEER QREEQLVSFD SHEEWNQMQS QEDEVAITEQ DLELIKERET AIRQLEADIL DVNQIFKDLA MMIHDQGDLI DSIEANVESS EVHVERATEQ LQRAAYYQKK SR
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, E. coli
Purity
~90% (SDS-PAGE)
Concentration
~0.5mg/ml
Form
Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 1mM DTT, 0.2M sodium chloride, 20% glycerol.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Tang B L., et al. (1998) J Biol Chem. 273:6944-6950. 2. Prekeris R., et al. (1998) J Cell Biol. 143: 957-971.
USBio References
No references available
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