WISP2, Recombinant, Human CAS

Grade

Highly Purified

EU Commodity Code

30021019

Shipping Temp

Blue Ice

Storage Temp

-20°C

CTGFL/WISP-2 is a 24.3kD protein that belongs to the CCN family of cysteine rich regulatory proteins. Members of this family stimulate mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest, and migration of multiple cell types. The protein is expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart. In addition to promoting adhesion of osteoblasts, CTGFL/WISP-2 inhibits osteocalcin production, as well as binding of fibrinogen to integrin receptors. Recombinant human CTGFL/WISP-2 is a 24.3kD protein of 228aa.

Source

Recombinant protein corresponding to human CTGFL, expressed in E.coli.

Biological Activity

Determined by its ability to inhibit IGF-II induced proliferation of MCF-7. The ED50 was found to be between 10-20ng/ml in the presence of 15ng/ml of human IGF-II.

Endotoxin

<0.1ng/ug (1EU/ug)

AA Sequence

MQLCPTPCTC PWPPPRCPLG VPLVLDGCGC CRVCARRLGE PCDQLHVCDA SQGLVCQPGA GPGGRGALCL LAEDDSSCEV NGRLYREGET FQPHCSIRCR CEDGGFTCVP LCSEDVRLPS WDCPHPRRVE VLGKCCPEWV CGQGGGLGTQ PLPAQGPQFS GLVSSLPPGV PCPEWSTAWG PCSTTCGLGM ATRVSNQNRF CRLETQRRLC LSRPCPPSRG RSPQNSAF

Storage and Stability

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Source

E. coli

Purity

~95% (SDS-PAGE and HPLC)

Concentration

As reported

Form

Supplied as a lyophilized powder.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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149606 WISP2, Recombinant, Human (WNT1-inducible-signaling Pathway Protein 2, WISP-2, CCN Family Member 5, CCN5, Connective Tissue Growth Factor-like Protein, CTGF-L, CTGFL, Connective Tissue Growth Factor-related Protein 58, CT58, UNQ228/PRO261) CAS:

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