Fractalkine is a CX3CL chemokine that signals through the CX3CR1 receptor. Fractalkine has been shown to chemoattract monocytes, microglia cells and NK cells. Recombinant rat Fractalkine is an 8.7kD protein containing 76aa, including the four conserved cysteine residues present in CC chemokines.
Source
Recombinant protein corresponding to rat Fractalkine, expressed in E.coli.
Biological Activity
Determined by its ability to chemoattract human monocytes using a concentration range of 5-10ng/ml.
Endotoxin
<0.1ng/ug (1EU/ug)
AA Sequence
QHLGMTKCNI TCHKMTSPIP VTLLIHYQLN QESCGKRAII LETRQHRHFC ADPKEKWVQD AMKHLDHQT AALTRNG
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity
~98% (SDS-PAGE and HPLC)
Form
Supplied as a lyophilized powder.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
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