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149786 Il16, Recombinant, Mouse, aa22-287, His-Tag (Pro-interleukin-16, Interleukin-16, IL-16, Lymphocyte Chemoattractant Factor, LCF) CAS:

Specifications
References
Grade
Highly Purified
Molecular Weight
29
EU Commodity Code
30021019
Shipping Temp
Dry Ice
Storage Temp
-70°C

IL-16 was initially identified as a chemotactic cytokine, but is now known to possess a wide range of activities. Later studies have more fully characterized IL-16 as an immunomodulatory cytokine that contributes to the regulatory process of CD4+ T cell recruitment and activation at sites of inflammation in association with asthma and several autoimmune diseases. The precursor of IL-16 (pro-IL-16) is thought to be cleaved towards the C-terminal region by Caspase-3, releasing a 20kD active form that binds to and signals through CD4. Besides acting as a chemotactic cytokine, IL-16 is thought to also be involved in the regulation of T cell proliferation and multiple infectious, immune-mediated, and autoimmune inflammatory disorders including irritable bowel syndrome, systemic lupus erythematosus, and neurodegenerative disorders. At least two isoforms of IL-16 are known to exist; the longer isoform (also known as NIL-16) is detected only in neurons of the cerebellum and hippocampus. This recombinant protein fragment is derrived from this longer isoform.

Source
Recombinant protein corresponding to mouse IL-16, fused to His-tag at C-terminal expressed in E.coli.
Molecular Weight
~29kD
Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Source
E. coli
Purity
~95%
Concentration
As reported
Form
Supplied as a liquid in 20mM Tris, 0.5M sodium chloride, 250mM Imidazole, 5mM beta-mercaptoethanol, 10% glycerol.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Cruikshank WW, Center DM, Nisar N, et al. Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD expression. Proc. Natl. Acad. Sci. USA 1994; 91:5109-13. 2. Interleukin-16. Cruikshank WW, Kornfeld H, and Center DM. J. Leukoc. Biol. 2000; 67:757-66. 3. Zhang Y, Center DM, Wu DM, et al. Processing and activation of pro-interleukin-16 by caspase-3. J. Biol. Chem. 1998; 273:1144-9. 4. Maciaszek JW, Parada NA, Cruikshank WW, et al. IL-16 represses HIV-1 promoter activity. J. Immunol. 1997; 158:5-8.
USBio References
No references available
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