2-Bromo 17β-Estradiol CAS 15833-07-5

CAS Number

15833-07-5

Grade

Highly Purified

Molecular Formula

C18H23BrO2

Molecular Weight

351.28

EU Commodity Code

38220090

Shipping Temp

Storage Temp

4°C

2-Bromo-estradiol; 2-Bromo-1,3,5(10)-estratriene-3,17β-diol; 2-Bromo-β-estradiol; 2-Bromoestradiol; NSC 105460

17β-Estradiol (E888000) metabolite. An inhibitor of androstenedione aromatization, which is responsible for the conversion of androgens to estrogens. Agonistic ligands for the estrogen receptor in MCF-7 breast cancer cells.

Melting Point

197-199°C

Solubility

DMSO, Methanol

Method for Determining Identity

Proton NMR (DMSO-d6) and MS

TLC Conditions

SiO2; Dichloromethane : Methanol (9 : 1). Visualized with UV and AMCS (single spot; Rf=0.55).

Storage and Stability

Store in the dark at 4°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Source

Synthetic

Purity

~98%

Form

Supplied as an off-white solid

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards

All products should be handled by qualified personnel only, trained in laboratory procedures.

References

Numazawa, M. et al.: J. Steroid. Biochem. Mol. Biol., 96, 51 (2005); Vollmer, G. et al.: J. Seroid. Biochem. Mol. Biol., 39, 359 (1991); Brueggemeier, R. et al.: J. Steroid. Biochem., 21, 709 (1984)