PHA 767491 Dihydrochloride Salt CAS

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165897 PHA 767491 Dihydrochloride Salt CAS:

Specifications

References

Grade

Highly Purified

Molecular Formula

C12H13Cl2N3O

Molecular Weight

286.16000000000002501

EU Commodity Code

38220090

Shipping Temp

Storage Temp

RT/4°C

1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one Dihydrochloride;PHA 767491 Dihydrochloride Salt; PF-02334471;

A potent and selective ATP-competitive dual inhibitor cdc7/cdk9. It blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2).

Melting Point

>300°C

Solubility

DMSO, Water

References

Anderson, D.R. et al.: J. Med. Chem., 50, 2647 (2007); Montagnoli, A. et al.: Nature Chem. Biol., 4, 357 (2008); Charych, D.H. et al.: J Cell. Biochem., 104, 1075 (2008); Jackson, P.K. et al.: Nature Chem. Biol., 4, 331 (2008);