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168595 Rabbit Anti-ZNF148 (Zinc Finger Protein 148, Transcription Factor ZBP-89, Zinc Finger DNA-binding Protein 89, ZBP89) (Not for Export EU)

Specifications
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q9UQR1
Isotype
IgG
Grade
Serum
Applications
E WB
Crossreactivity
Hu
Gene ID
256711
Shipping Temp
Blue Ice
Storage Temp
-20°C

The GI tract abundantly expresses growth factors many of which bind and activate the EGF receptor present on mucosal cells. One such factor is the zinc finger protein (ZBP-89) that binds to a GC-rich DNA element in the gastrin promoter and confers EGF responsiveness. The full-length protein functions as a repressor of growth factor signals regulating the gastrin promoter. Several other growth related promoters are also regulated by ZBP-89. ZBP-89 is one of a family of related transcriptional regulators. It has been reported in recent studies that ZBP-89 regulates growth in part by stimulating the cyclin-dependent kinase inhibitor, p21waf1, in a butyrate-dependent manner through recruitment of the histone acetyl transferase p300. Moreover, ZBP-89 triggers growth arrest in a p53-dependent manner by preventing nuclear export of p53. ZBP-89 also induces apoptosis, but this process occurs independent of p53.

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilutions
ELISA: 1:10,000-1:30,000 Western Blot: 1:5000, band at ~89kD Optimal dilutions to be determined by the researcher.
Positive Control
Human monocytes or macrophages or nuclear extracts from PMA treated U937 cells
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Full length recombinant protein corresponding to human ZBP-89 expressed in E.coli.
Form
Supplied as a liquid, 0.09% sodium azide.
Purity
Serum
Specificity
Recognizes human ZBP-89.
Conjugates
Pricing
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