A77 1726-d4 CAS 1185240-22-5

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A0001-67G A77 1726-d4 (N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide-d4, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide-d4, LEF-M-d4) CAS: 1185240-22-5

Specifications

CAS Number

1185240-22-5

Grade

Highly Purified

Molecular Formula

C12H5D4F3N2O2

Molecular Weight

274.23

EU Commodity Code

38220090

Shipping Temp

Storage Temp

-20°C

N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide-d4, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide-d4, LEF-M-d4

The active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function.

Source

Synthetic

Purity

~90%

Form

Supplied as a white solid

Solubility

DMSO (Heated)

Melting Point

220-223ºC

Method for Determining Identity

Proton NMR and Mass Spectroscopic Analysis

TLC Conditions

SiO2: Ethyl Acetate: Hexane: Acetic acid; 7ml: 3ml: 5 drops; Visualized with UV and AMCS; Single spot; Rf=0.35.

Storage and Stability

May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.