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A0650-01B Rabbit Anti-ACK1, phosphorylated (Tyr284) (Activated CDC42 Kinase 1, ACK-1, ACK, p21cdc42Hs, Tyrosine Kinase Non-receptor Protein 2, TNK2)

Specifications
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q07912
Isotype
IgG
Grade
Affinity Purified
Applications
WB
Crossreactivity
Hu
Gene ID
10188
Shipping Temp
Blue Ice
Storage Temp
-20°C
EC=2.7.10.2, Tyrosine Kinase, Non-receptor, 2

Ack1 and Ack2 (activated cdc42-associated kinase 1 and 2) are non-receptor tyrosine kinases that consist of a tyrosine kinase core, an SH3 domain, a cdc42/Rac-binding (CRIB) domain, a Ralt homology region and a proline-rich region (1,2). Ack1 and 2 are the only two tyrosine kinases known to interact with cdc42. Both Acks are activated by growth factors including EGF and PDGF, as well as by activated integrins through cell adhesion, and may serve to link receptor tyrosine kinase or G protein-coupled receptor signaling with cdc42. Acks may regulate cell growth, morphology and motility (3,4). Recent findings indicate that Ack1 may play a role in prostate tumorigenesis, making it a potential drug target for this type of cancer (5).

Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Tyr284 of human Ack1. Species Sequence Homology: Mouse and rat (100%)
Form
Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
Purity
Purified by peptide affinity chromatography.
Specificity
Recognizes transfected levels of human Ack1 only when phosphorylated at Tyr284.
Conjugates
Pricing
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