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A0886-75J Rabbit Anti-Adiponectin Receptor 1 (ADIPOR1, ACDCR1, CGI45, CGI-45, FLJ25385, FLJ42464, PAQR1, Progestin and AdipoQ Receptor Family Member I, TESBP1A)

Specifications
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C

The adiponectin receptors, ADIPOR1 and ADIPOR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-alpha (PPARA) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin. ADIPOR1 and ADIPOR2 are highly related structurally, and mouse Adipor1 and Adipor2 share 66.7% identity. ADIPOR1 and ADIPOR2 are 7-transmembrane domain proteins, but they are structurally, topologically, and functionally distinct from G proteincoupled receptors (GPCRs). The mouse, human, and rat Adipor1 protein (ADIPOR1) contains 375 aas (with a predicted MW of 42.4 kD). Human and mouse ADIPOR1 have 96.8% homology. ADIPOR1 has high-affinity receptor for globular adiponectin (gACRP30) but low-affinity receptor for full-length adiponectin. ADIPOR1 is widely expressed. It is highly expressed in skeletal muscle. It is expressed at intermediate levels in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. It is weakly expressed in colon, thymus and small intestine.

Applications
Suitable for use in ELISA. Other applications not tested.
Recommended Dilutions
ELISA: 1:1600 (0.625ug/ml) Optimal dilutions to be determined by the researcher.
Amino Acid Sequence
Asn-Leu-Gln-Glu-Phe-Arg-Tyr-Gly-Leu-Glu-Gly-Gly-Cys-Thr-Asp-Asp-Thr-Leu-Leu
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Synthetic peptide corresponding to aa357-375 of human Adiponectin Receptor 1.
Form
Supplied as a lyophilized powder from PBS. Reconstitute with 200ul sterile PBS.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes human Adipo R1.
Conjugates
Pricing
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