Aldolase (fructose bisphosphate aldolase), a glycolytic enzyme, catalyzes the conversion of fructose 1, 6-bisphosphate to 3-phosphoglyceraldehyde. This ubiquitous enzyme is present as three different isozymes: aldolase A, aldolase B and aldolase C. Studies suggest the potential diagnostic value of quantitive anlysis of aldolase A for hepatocarcinoma (1). Furthermore, the change of aldolase B gene expression levels has also been observed in certain patients with this primary tumor (2,3).