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A2295-15K2 ANXA11, aa1-505, Recombinant, Human (Annexin A11, 56kD Autoantigen, Annexin XI, Annexin-11, Calcyclin-associated Annexin 50, CAP-50, ANX11) CAS:

Specifications
References
Grade
Highly Purified
Accession Number
NP_001148
Molecular Weight
56.6
EU Commodity Code
30021019
Shipping Temp
Blue Ice
Storage Temp
-20°C

ANXA11 (Annexin A11) is a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. ANXA11 binds specifically to calcyclin in a calcium-dependent manner. And it required for midbody formation and completion of the terminal phase of cytokinesis. This protein is a 56kD antigen recognized by sera from patients with various autoimmune diseases.

Source
Recombinant corresponding to aa1-505 of human ANXA11 protein, fused to His-tag at N-terminus, expressed in E.coli.
AA Sequence
MGSSHHHHHH SSGLVPRGSH MSYPGYPPPP GGYPPAAPGG GPWGGAAYPP PPSMPPIGLD NVATYAGQFN QDYLSGMAAN MSGTFGGANM PNLYPGAPGA GYPPVPPGGF GQPPSAQQPV PPYGMYPPPG GNPPSRMPSY PPYPGAPVPG QPMPPPGQQP PGAYPGQPPV TYPGQPPVPL PGQQQPVPSY PGYPGSGTVT PAVPPTQFGS RGTITDAPGF DPLRDAEVLR KAMKGFGTDE QAIIDCLGSR SNKQRQQILL SFKTAYGKDL IKDLKSELSG NFEKTILALM KTPVLFDIYE IKEAIKGVGT DEACLIEILA SRSNEHIREL NRAYKAEFKK TLEEAIRSDT SGHFQRLLIS LSQGNRDEST NVDMSLAQRD AQELYAAGEN RLGTDESKFN AVLCSRSRAH LVAVFNEYQR MTGRDIEKSI CREMSGDLEE GMLAVVKCLK NTPAFFAERL NKAMRGAGTK DRTLIRIMVS RSETDLLDIR SEYKRMYGKS LYHDISGDTS GDYRKILLKI CGGND
Molecular Weight: 56.6kD (525aa) confirmed by MALDI-TOF
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Recombinant, E. coli
Purity
~95% (SDS-PAGE).
Concentration
~0.25mg/ml
Form
Supplied as a liquid in PBS, 20% glycerol, 2mM DTT, 100mM sodium chloride.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Tomas A., et al. (2004) J. Cell Biol. 165:813-822. 2. Satoh., et al. (2002) Biochem. Biophys. Res. Commun. 291(5): 1166-72.
USBio References
No references available
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