The p11 protein belongs to a family of small dimeric proteins which share sequence homologies with S100a and S100b. It is closely related to serotonin transmission in the brain -- and may play a key role in determining suseptability to depression.
In addition, the p11 could be involved in regulating pain via the Nav1.8 pathway.Changes in the extracellular expression of the plasminogen receptor protein, p11, dramatically affect tumor cell-mediated pericellular proteolysis
Applications
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution
Immunohistochemistry: 1:100-600 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Synthetic peptide (CNQKDPLAVDK)
Form
Supplied as a liquid in PBS, 0.05% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes rat Annexin II.
TDS
NCBI
UniProt
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