APG16 L1 plays an essential role in autophagy. SUBUNIT: Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400kD) or 8 sets of ATG12-ATG5 and ATG16L1 (800kD).
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