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A3913-12 Mouse Anti-AT Rich Interactive Domain 1A (ARID1A, B120, BAF250, BAF250a, BM029, C1orf4, P270, SWI-like, SMARCF1)

Specifications
Clone Type
Monoclonal
Host
Mouse
Source
Human
Isotype
IgG1
Clone Number
8C22
Grade
Affinity Purified
Applications
WB
Crossreactivity
Hu
Accession #
NM_006015
Shipping Temp
Blue Ice
Storage Temp
-20°C

This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.

Applications
Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Recommended Dilution
Immunocytochemistry: 2-100ug/ml Optimal dilutions to be determined by the researcher.
Positive Control
HeLA cells
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Partial sequence of recombinant protein to human ARID1A.
Form
Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.
Purity
Purified by Protein G affinity chromatography from hybridoma culture supernatant
Specificity
Recognizes human AT Rich Interactive Domain 1A.
Conjugates
Pricing
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