Avermectin B1a CAS 65195-55-3

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A4447 Avermectin B1a (5-O-Demethylavermectin A1a, Antibiotic C 076B1a) CAS: 65195-55-3

Specifications

References

CAS Number

65195-55-3

Grade

Highly Purified

Molecular Formula

C48H72O14

Molecular Weight

873.1

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

5-O-Demethylavermectin A1a, Antibiotic C 076B1a.

Avermectin B1a is the major component (>80%) of the commerically available anthelmintic Abamectin (R) used to control parasitic nematodes in livestock. Avermectin B1a contains a secbutyl residue in the 24-position. In vitro and in vivo studies have shown this analogue is the more potent analogue in the commerical product.

Purity: >99% by HPLC

Solubility: Soluble in ethanol, methanol, DMF or DMSO.

Related to: Avermectin B1b, Milbemycin A4, Milbemycin A3, Milbemycin D, Nemadectin

Source

Streptomyces avermitilis

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Avermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by |reducing muscle membrane resistance. Fritz L.C. et al. Proc. Natl Acad. Sci. USA 1979, 76, 2062. |2. Solubilization and characterization of a high affinity ivermectin binding site from Caenorhabditis elegans. |Cully D.F. et al. Mol Pharmacol. 1991, 40, 326. |3. Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. |Wolstenholme A.J. & Rogers A.T. Parasitology 2005, 131, S85-95.