USBio Logo
Subscribe to our newsletter!

REGISTER | SIGN IN

Welcome | LOG OUT

B0003-84G Rabbit Anti-BAG1 (BAG Family Molecular Chaperone Regulator 1, BAG-1, BCL-2 Associated Athanogene 1, BCL-2-associated Athanogene 1, BCL2-associated Athanogene, RAP46)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q99933
Isotype
IgG
Grade
Affinity Purified
Applications
WB
Crossreactivity
Hu Mo
Shipping Temp
Blue Ice
Storage Temp
-20°C

The BAG1 gene encodes three different isoforms; a predominantly cytosolic form of ~36kD (BAG1S), a ~46kD cytosolic and nuclear form (BAG1M), and a predominantly nuclear form of ~50kD (BAG1L).

BAG1 displays potent neuroprotective activity in vivo against stroke, and could be used for reducing brain injury during cerebral ischemia and neurodegenerative diseases. BAG1 may also promote chemoresistance, growth factor independence, and anchorage independent cell growth in tumor cells.
Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1-2ug/ml, detects a band of ~35kD in PC-3 cell lysate. Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to 14aa near the N-terminus of human BAG1.
Form
Supplied as a liquid, 0.02% sodium azide.
Purity
Purified by affinity chromatography.
Specificity
Recognizes human BAG1, NT. Species Crossreactivity: mouse.
References
1. Gotz, R. et al. (2005) Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. Nat. Neurosci. 8: 1169-1178. 2. Liman, J. et al. (2005) Interaction of BAG1 and Hsp70 mediates neuroprotectivity and increases chaperone activity. Mol. Cell Biol. 25: 3715-3725. 3. Krajewska, M. et al. (2006) Expression of BAG-1 protein correlates with aggressive behavior of prostate cancers. Prostate. 66: 801-810. 4. Clemo, N.K. et al. (2005) The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival. Biochem. Soc. Trans. 33: 676-678.
USBio References
No references available
Conjugates
Pricing
Order
Proceed to Checkout
Cart Summary
ProductSizeListYour PriceQtyExt Price
Subtotal:Subtotal:
Subtotal:Subtotal:
Total Coupon Savings:Total Coupon Savings:()
Your cart is currently empty.
- Coupon Code
Recently Viewed
Special Offers
30% OFF New Lab Discount Setting up a New Lab?
Apply for our New Lab Discount!
*Receive a 30% off LIST price coupon code via email.
Society Member Discount Members of the GSA, FASEB, ACS and SFN get even bigger discounts!
  • Earn Research Credit Try any antibody for an unspecified use. We'll reward you for your efforts!
    *Receive a 25% off list price coupon code.
    • Contact Us

    Visit our technical library or contact our support staff to answer your questions.

    Telephone:
    1-800-520-3011

    Library | Contact

    Site Map

    ANTIBODIES

    BIOCHEMICALS

    BIOLOGICALS

    CULTURE MEDIA

    MOLECULAR BIOLOGY

    KITS AND ASSAYS

    Technical Resources

    BIO DICTIONARY

    CITEAB

    ENTREZ GENE

    GENBANK

    HISTOLOGY GUIDE

    NCBI

    OMIM

    PROTEIN RESOURCES

    PROTOCOLS

    PUBMED

    UNIPROT

    Distributors

    For customers outside of the United States, please use one of our many distributors.

    View Distributors

    Payment Methods

    We accept the following payment methods as well as pay-by-invoice.

    MasterCard Visa PayPal
    © 2023-2024 United States Biological - All Rights Reserved