Vascular cell adhesion molecule-1 (VCAM-1, CD106) is a member of the immunoglobulin gene superfamily. Two forms of VCAM-1 with six or seven extracellular Ig-like domains arise due to alternative splicing from a seven-domain VCAM-1 (7D VCAM-1). 7D VCAM-1 is the dominant form expressed by cultured human endothelial cells (1,2). Homology of domains 1 through 3 with domains 4 through 6 suggests a gene duplication event (1,2). The cDNA of 7D VCAM-1 predicts a core protein of approximately 81kD with seven sites for N-linked glycosylation. Upon complete glycosylation the mature protein has a molecular weight of approximately 102kD. This observation is in general agreement with the 110kD protein immunoprecipitated from cytokine-activated endothelium (3,4).
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