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C2589-99 Cefoperazone, Sodium Salt (CP-52640-2, T-1551, Bioperazone, Cefazone, Cefobid) CAS: 62893-20-3

Specifications
References
CAS Number
62893-20-3
Grade
Highly Purified
Molecular Formula
C25H26N9NaO8S2
Molecular Weight
667.65
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
CP-52640-2, T-1551, Bioperazone, Cefazone, Cefobid; (6R,7R)-7-[[(2R)-2-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt

Cefoperazone is a third generation cephalosporin antibiotic. Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis, and sulbactam acts as a beta-lactamase inhibitor, to increase the antibacterial activity of cefoperazone against beta-lactamase producing organisms. It is one of few cephalosporin antibiotics effective in treating Pseudomonas bacterial infections which are otherwise resistant to these antibiotics.

Melting Point
>184ºC (dec)
Solubility
Water (Sparingly), Methanol (Slightly heated)
Atmosphere
Inert Gas
Method for Determining Identity
Proton NMR (D2O) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions
C18; Acetonitrile: Water: Ammonium Hydroxide; 8: 2: 0.2: Visualized with UV and AMCS; Single spot, Rf=0.70.
Specific Rotation
-22.2º (c=1.1, Water)
Acetone Content
1%
Elemental Analysis
Calculated: %C: 44.97, %H: 3.93, %N: 18.88
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic. Store under inert atmosphere.
Purity
≥95%
Form
Supplied as a white solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Borobio, M.V., et al.: Antimicrob. Agents Chemother., 17, 129 (1980). 2. Brogden, R.N., et al.: Drugs, 22, 423 (1981)
USBio References
No references available
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