Isolated from Cercosporidium henningsii, cercosporamide was originally identified as a host-selective phytotoxin and broad spectrum antifungal agent. More recently cercosporamide was shown to inhibit a cell wall integrity pathway mediated through a serine/threonine protein kinase, Pkc1, that is central to cell wall biosynthesis. It is both potent (IC50 < 50nM) and selective for Pkc1 kinase inhibition.
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