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C5032-05 Chlorothricin (Antibiotic K 818A) CAS: 34707-92-1

Specifications
References
CAS Number
34707-92-1
Grade
Highly Purified
Molecular Formula
C50H63ClO16
Molecular Weight
955.48
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
+4°C
Antibiotic K 818A

The tetronic acid, chlorothricin is an unusual macrocyclic antibiotic from a Streptomyces sp.. It shows inhibitory activity against cholesterol biosynthesis from mevalonate and inhibits pyruvate carboxylases purified from rat liver, chicken liver and Azotobacter vinelandii.

Solubility: Soluble in ethyl acetate, ethanol, methanol, DMF or DMSO.
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ethyl acetate, ethanol, methanol, DMF or DMSO..Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Streptomyces sp.
Purity
~ 99% by HPLC
Form
Supplied as a white powder.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. New cholesterol biosynthesis inhibitors MC-031 (O-demethylchlorothricin), -032 (O-demethyl hydroxy-chlorothricin), -033 and -034. Kawashima A. et al.,J. Antibiot. 1992, 45, 207. 2. Mode of action of the macrolide-type antibiotic, chlorothricin. Effect of the antibiotic on the catalytic activity and some structural parameters of pyruvate carboxylases purified from rat and chicken liver. Schindler P.W. et al. Eur. J. Biochem. 1975, 55, 543.
USBio References
No references available
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