CI-994, Free Base CAS 112522-64-2

CAS Number

112522-64-2

Grade

Highly Purified

Molecular Formula

C15H15N3O2

Molecular Weight

269.3

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

CI-994 is a histone deacetylase (HDAC) inhibitor and induces histone hyperacetylation in living cells. CI-994 inhibited HDAC-1 and HDAC-2 but not the prototypical histone acetyltransferase GCN5.

Melting Point

235-242ºC

Solubility

Soluble in DMSO at 66mg/ml; very poorly soluble in ethanol and water; maximum solubility in plain water is estimated to be about 25-100uM. Buffers, serum, or other additives may increase or decrease the aqueous solubility.

Elemental Anaylsis

Calculated: C=66.90% H=5.61% N=15.60%

Storage and Stability

May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Purity

~99%

Form

Supplied as a white to off-white powder.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Kraker, A.J., et al. "Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma." Mol. Cancer Ther. 2:401-408 (2003). 2. Hubeek, I., et al. "CI-994 (N-acetyl-dinaline) in combination with conventional anti-cancer agents is effective against acute myeloid leukemia in vitro and in vivo." Oncol. Rep. 19:1517-1523 (2008). 3. LoRusso, P.M., et al. "Preclinical antitumor activity of CI-994." Invest. New Drugs 14:349-356 (1996). 4. Loprevite, M., et al. "in vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines." Oncol. Res. 15:39-48 (2005).

USBio References

No references available

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C5071-65 CI-994, Free Base (4-(Acetylamino)-N-(2-aminophenyl)benzamide, Acetyldinaline, 5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine, Goe 5549, Gö 5549, PD 123654, Tacedinaline) CAS: 112522-64-2

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