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C8845 Cyclopamine (11-Deoxyjervine) CAS: 4449-51-8

Specifications
CAS Number
4449-51-8
Grade
Highly Purified
Molecular Formula
C27H41NO2
Molecular Weight
411.62
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
11-Deoxyjervine

Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumor suppressor Patched (Ptch) both of which encode multipass transmembrane proteins. Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle.

Purity
≥ 99%
Melting Point: 236-238°C
Solubility: Chloroform, DMSO (1mg/200ul), hot methanol
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Form
White Crystalline Solid
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
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