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D3221-94A Desthiazolylmethyloxycarbonyl Ritonavir CAS: 176655-55-3

Specifications
References
CAS Number
176655-55-3
Grade
Highly Purified
Molecular Formula
C₃₂H₄₅N₅O₃S
Molecular Weight
579.8
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
(2S)-N-[(1S,3S,4S)-4-Amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-3-methyl-2-[[[methyl[[2-(1-methylethyl)-4-thiazolyl]methyl]amino]carbonyl]amino]butanamide

An analogue of the selective HIV protease inhibitor Ritonavir.

Synonyms
(2S)-N-[(1S,3S,4S)-4-Amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-3-methyl-2-[[[methyl[[2-(1-methylethyl)-4-thiazolyl]methyl]amino]carbonyl]amino]butanamide
CAS No
176655-55-3
Molecular Formula
C₃₂H₄₅N₅O₃S
Molecular Weight
579.8
Purity
≥96%
Appearance
White to pale beige solid
Melting Point
69-75°C (lit)
Solubility
Chloroform (Slightly), Methanol (Slightly)
Method for Determining Identity
Proton NMR and Mass Spectrometric Analysis
TLC Conditions
SiO2; Dichloromethane: Methanol: Ammonium Hydroxide=9:1:01; Visualized with UV and AMCS; Single Spot, Rf=0.35
Specific Rotation (c=0.5, Methanol)
As Reported
Elemental Analysis
Calculated: %C: 66.29, %H: 7.82, %N: 12.08
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Jaworski, T., et al.: Xenobiotica, 21, 1451 (1991). 2. Lee, S., et al.: Biochem. Pharmacol., 49, 1567 (1995). 3. Zhang, X., et al.: Drug Metab. Dispos., 24, 23 (1996)
USBio References
No references available
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