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G1009-02A Rabbit Anti-G9a (EHMT2, BAT8, C6orf30, Em:AF134726.3, Euchromatic histone-lysine N-methyltransferase 2, G9A, H3-K9-HMTase 3, Histone H3-K9 methyltransferase 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, HLA-B-associated transcript 8, NG36, NG36/G9a, Protein G9a )

Specifications
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q96KQ7
Isotype
IgG
Grade
Affinity Purified
Applications
WB
Crossreactivity
Hu Mo
Accession #
NP_006700.3
Shipping Temp
Blue Ice
Storage Temp
-20°C

G9a (BAT8 or Histone-lysine N-methyltransferase) is thought to be involved in intracellular protein-protein interaction and is a lysine-preferring histone methyltransferase. H3 Lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. The presence of the ankyrin repeats also suggests that G9a is involved in intracellular protein-protein interaction. Like Suv39h1, G9a transfers methyl groups to the lysine residues of histone H3, but with a 10- to 20-fold higher activity. G9a is localized to the nucleus but not in the repressive chromatin domains of centromeric loci, in which Suv39h1 family proteins were localized. This protein is probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. G9a also methylates histone H1.

Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 0.25-2ug/ml detected G9a (BAT8) on 10ug of HeLa cell lysate. Optimal dilutions to be determined by the researcher.
Positive Control
HeLa cell lysate
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated linear peptide corresponding to G9a (BAT8). Cellular Localization: Nucleus. Species sequence homology: rat and canine.
Form
Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 0.15mM sodium chloride, 0.05% sodium azide.
Purity
Purified by affinity chromatography.
Specificity
Recognizes human G9a. Species Crossreactivity: mouse.
Conjugates
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