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G2004-40 Ganciclovir CAS: 82410-32-0

Specifications
References
Brand
BioReagent™
CAS Number
82410-32-0
Grade
Highly Purified
MDL Number
MFCD00870588
Molecular Formula
C₉H₁₃N₅O₄
Molecular Weight
255.23
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one; |2’-NDG; 2’-Nor-2’-deoxyguanosine; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine; BW 759; BW 759U; BW-B 759U; Biolf 62; DHPG; Denosine; Gancyclovir; Ganguard; Ganquard; HHEMG; Hydroxyacyclovir; Natclovir; RS 21592; Vitrasert

Ganciclovir (GCV) is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research. Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. The cell cycle is irreversibly arrested at the G2-M checkpoint. Gap junction involvement in the ganciclovir bystander effect has been studied. Ganciclovir has been used to study loss of telomeres and to evaluate sensitivity of viruses to antiviral treatments. Ganciclovir is used in molecular biology for selection against random recombination events when homologous recombination of a gene of interest is required.

Synonyms
2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one; 2’-NDG; 2’-Nor-2’-deoxyguanosine; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine; BW 759; BW 759U; BW-B 759U; Biolf 62; DHPG; Denosine; Gancyclovir; Ganguard; Ganquard; HHEMG; Hydroxyacyclovir; Natclovir; RS 21592; Vitrasert
CAS No
82410-32-0
Molecular Formula
C₉H₁₃N₅O₄
Molecular Weight
255.23
Appearance
Supplied as a white to off-white solid
Purity
≥98%
Melting Point
245-248ºC (lit)
Method for Determining Identity
Proton NMR Spectroscopic Analysis
Storage and Stability
Store at -20ºC. Stable for 6 months after receipt.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards:  All products should be handled by qualified personnel only, trained in laboratory procedures.
Source
Synthetic
Purity
≥98% (HPLC)
Form
Supplied as a white to off-white solid
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. J. Med. Virol. 70(2): 240-243 (2003). 2. J. Clin. Exp. Immunol. 129(1): 19-26 (2002). 3. J. Med. Virol. 65(3): 537-542 (2001). 4. J. Virol. 72(8): 57-64 (1998). 5. AIDS Res. Hum. Retroviruses 14(6): 533-536 (1998). 6. J. Infect. Dis. 175(1): 179-184 (1997). 5.Halloran, P.J. and Fenton, R.G.: Cancer Res., 58, 3855 (1998), Rubsam, L.Z., et al.: Cancer Res., 59, 669 (1999), Yamasaki, H., et al.: C.R. Acad. Sci. III, 322, 151 (1999)
USBio References
No references available
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