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G3026-01 Gliotoxin CAS: 67-99-2

Specifications
CAS Number
67-99-2
Grade
Highly Purified
Molecular Formula
C13H14N2O4S2
Molecular Weight
326
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Gliotoxin is a potent epithiodioxopiperazine mycotoxin produced by species in the genera Gliocladium, Aspergillus and Penicillium. At the cellular level gliotoxin has been shown to inhibit a broad range of unrelated mechanisms, such as inhibition of chymotrypsin-like activity of the 20S proteasome, Ca2+ release from mitochondria, activation of transcription factor NF-κB in response to a variety of stimuli in T and B cells, anti-inflammatory activity and inhibition of farnesyltransferase and geranyl- geranyltransferase. The mode of action appears to be via covalent binding to proteins through mixed disulphide formation. Gliotoxin has been shown to inhibit a number of thiol-requiring enzymes and also displays antioxidant and immunomodulatory activity.

Source
Gliotoxin from Gliocladium fimbriatum.
Molecular Weight
~326
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity
~99% (HPLC)
Concentration
Not determined
Form
Supplied as a white powder.
Pricing
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