GRO alpha, Recombinant, Human CAS

Grade

Highly Purified

Swiss Prot

P09341

Gene ID

2919

Molecular Weight

7.81

EU Commodity Code

30021019

Shipping Temp

Blue Ice

Storage Temp

-20°C

BSA Free

Yes

Notes

BSA Free

All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. GRO/MGSA also stimulates mitogenesis in certain human melanoma cells. Recombinant Human GRO-a/MGSA is a 7.8kD protein consisting of 73 amino acids, including the 'ELR' motif common to the CXC chemokine family that binds to CXCR1 or CXCR2.

Amino Acid Sequence

ASVATELRCQ CLQTLQGIHP KNIQSVNVKS PGPHCAQTEV IATLKNGRKA CLNPASPIVK KIIEKMLNSD KSN

Biological Activity

Determined by its ability to chemoattract human neutrophils using a concentration range of 10-50ng/ml.

Storage and Stability

Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O, 0.1% BSA or HSA. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Source

Recombinant, E. coli

Form

Supplied as a lyophilized powder. No additives. Reconstitute with sterile ddH2O to a concentration of 0.1-1mg/ml. Add 0.1% HSA or BSA for long term storage. Do not vortex.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Melanoma growth stimulatory activity in primary malignant melanoma: prognostic significance.||Mod Pathol 2002 May;15(5):532-7||2. A role for poly(ADP-ribose) polymerase in the transcriptional regulation of the melanoma growth stimulatory activity (CXCL1) gene expression.||J Biol Chem 2001 Mar 23;276(12):9366-74||3. Nuclear factor-kappa B activation by the CXC chemokine melanoma growth-stimulatory activity/growth-regulated protein involves the MEKK1/p38 mitogen-activated protein kinase pathway.||J Biol Chem 2001 Feb 2;276(5):3650-9||4. Melanoma growth stimulatory activity (MGSA/GRO-alpha) chemokine genes incorporated into an African green monkey simian cytomegalovirus-derived stealth virus.||Exp Mol Pathol 1999 Apr;66(1):15-8||5. Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine beta and g amma proteins.||Int J Cancer 1997 Sep 26;73(1):94 -103||6. Role of melanoma growth stimulatory activity (MGSA/gro) on keratinocyte function in wound healing.||Arch Dermatol Res 1997 Mar;289(4):204-12

USBio References

No references available

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G8975-16 GRO alpha, Recombinant, Human (MGSA, CXCL1) CAS:

Grade

Swiss Prot

Gene ID

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

BSA Free

Notes

References

USBio References

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