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H9111-27B Pravastatin Sodium Salt CAS: 81131-70-6

Specifications
CAS Number
81131-70-6
Grade
Highly Purified
Molecular Formula
C23H35O7 Na
Molecular Weight
446.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Pravastatin sodium is the sodium salt of pravastatin, a ring- opened member of the statin family. Pravastatin is produced biosynthetically from compactin (mevastatin) by a number of micro-organisms, notably Absidia, Cunninghamella, Syncephalastrum, Nocardia or Streptomyces. Typically, statins like compactin, lovastatin and simvastatin possess a b-hydroxy lactone ring which is a pro-drug for the readily ring-opened dihydroxyacid generally regarded as the active HMG-CoA inhibitor. Importantly, the free carboxylic acid enables pravastatin to be freely water soluble within biological pH ranges. Pravastatin is used therapeutically to reduce LDL cholesterol.

Source
Pravastatin from Absidia sp.
Molecular Weight
~446.5
Solubility
Soluble in water, methanol and DMSO.
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity
~98% (HPLC)
Concentration
Not determined
Form
Supplied as a white powder.
Pricing
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