HSD17b14 (hydroxysteroid (17beta)dehydrogenase type 14), also called 17bHSD14 or DHRS10, is a cytoplasmic 17beta hydroxy steroid dehydrogenase that is a member of the SDR (shortchain dehydrogenase/reductase) family. It is a 270aa, ~30kD protein with mRNA highly expressed in brain, placenta, liver and kidney. It converts estradiol to estrone, thus inactivating it, and is thought to regulate activity of estrogens and possibly dihydroepiandrosterone (DHEA) in the placenta and central nervous system. Human HSD17b14 shares 80.5% aa sequence identity with mouse and rat HSD17b14.
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