IP-10, Recombinant, Human CAS

Grade

Highly Purified

Swiss Prot

P02778

Gene ID

3627

Molecular Weight

8.6

EU Commodity Code

30021019

Shipping Temp

Blue Ice

Storage Temp

-20°C

BSA Free

Yes

Notes

BSA Free

Among CXC chemokines, CXCL10 has been identified to play an important role in several endocrinological autoimmune diseases such as Hashimoto's thyroiditis, Graves'disease and Type 1 diabetes mellitus.The chemokine IP-10 (interferon-inducible protein of 10 kD, CXCL10) is a chemoattractant for CXCR3+ T cells, binds to the G protein-coupled receptor CXCR3, which is found mainly on activated T cells and NK cells, and plays an important role in Th1-type inflammatory diseases. IP-10 also binds to glycosaminoglycans (GAGs), an interaction thought to be important for its sequestration on endothelial and other cells

Recombinant protein corresponding to human IP-10, expressed in E. coli. Swiss/Uniprot: P02778

Amino Acid Sequence

VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP

Biological Activity

Determined by its ability to chemoattract human T-Lymphocytes using a concentration of 10-50ng/ml

Storage and Stability

Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O containing 0.1% BSA or HSA. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Source

Recombinant, E. coli

Form

Supplied as a lyophilized powder without additives. Reconstitute with sterile ddH2O, 0.1% BSA or HSA to ≥0.1-1mg/ml

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Early post-transplant urinary IP-10 expression after kidney transplantation is predictive of short- and long-term graft function. Kidney Int 2006 May;69(9):1683-90 2. IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain. Circ Res 2006 Mar 17;98(5):617-25 3. Compartment-specific expression and function of the chemokine IP-10/CXCL10 in a model of renal endothelial microvascular injury. J Am Soc Nephrol 2006 Feb;17(2):454-64 4. IP-10/MCP-1 ratio in CSF is an useful diagnostic marker of neuropsychiatric lupus patients. Rheumatology (Oxford) 2006 Feb;45(2):232-4 5. T lymphocyte chemotactic chemokines in acute myelogenous leukemia (AML): local release by native human AML blasts and systemic levels of CXCL10 (IP-10), CCL5 (RANTES) and CCL17 (TARC). Cancer Immunol Immunother 2006 Jul;55(7):830-40 6. TLR3-mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: differential signaling mechanisms of TLR3-induced IP-10 and IL-8 gene expression. Glia 2006 Feb;53(3):248-56

USBio References

No references available

Product	Ext Price
Subtotal:	Subtotal:
Subtotal:	Subtotal:
Total Coupon Savings:	Total Coupon Savings:	()
Your cart is currently empty.
- Coupon Code

I8449-08N IP-10, Recombinant, Human (Interferon gamma Inducible Protein, CXCL10) CAS:

Grade

Swiss Prot

Gene ID

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

BSA Free

Notes

References

USBio References

Pricing

Order

Cart Summary

Recently Viewed

Special Offers

Contact Us

Site Map

Technical Resources

Distributors

Payment Methods