Deuterated Irinotecan, a DNA topoisomerase inhibitor.
Melting Point
258-260°C
Solubility
DMSO, Methanol (sparingly)
Method for Determining Identity
Proton Spectroscopic and Mass Spectrometric Analysis
SiO2; Dichloromethane
Methanol; 7:3 Visualized with UV and AMCS; Single spot; Rf=0.5.
Chlorine Content: 6.6%
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
1. Kunimoto, T., et al.: Cancer Res., 47, 5944 (1987),2. Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1993)