Isocyclosporin A CAS 59865-16-6

CAS Number

59865-16-6

Grade

Highly Purified

Molecular Formula

C62H111N11O12

Molecular Weight

1201.8

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

Isocyclosporin A is a rearranged degradation product formed by acid treatment oc cyclosporine A under in aqueous and non- aqueous conditions. This rearrangement has been used as the basis of a HPLC fluorescence for quantifying cyclosporin A. The pharmacology of isocyclosporin A has received little attention.

Solubility

Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

Storage and Stability

Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Source

Trichoderma sp.

Purity

98% (HPLC)

Concentration

Not determined

Form

Supplied as a white powder

References

1. Cyclosporin A, a peptide metabolite from Trichoderma polysporum, with remarkable immunosuppressive activity. Ruegger A. et al. Helv. Chim. Acta 1976, 59, 1075. 2. Hydrolysis of cyclosporin A: Identification of 1,11 seco-cyclosporin A and 4,5 seco-isocyclosporin A by FAB-MS/MS. Magni F. et al. Peptides 1995, 16, 1335. 3. Kinetics of acid-catalyzed degradation of cyclosporin A and its analogs in aqueous solution. Oliyai R. et al. Int. J. Pept. Protein Res. 1994, 43, 239. 4. Kinetics and mechanism of isomerization of cyclosporin A. Oliyai R. & Stella V. J. Pharm. Res. 1992, 9, 617. 5. Synthesis of a fluorescent derivative of cyclosporin A for high-performance liquid chromatography analysis. Fois R. A. & Ashley J. J. J. Pharm. Sci. 1991, 80, 363.

USBio References

No references available

Product	Size	List	Your Price	Qty	Ext Price
Subtotal:	Subtotal:
Subtotal:	Subtotal:
Total Coupon Savings:	Total Coupon Savings:	()
Your cart is currently empty.
- Coupon Code

Product

Size

List

Your Price

Qty

Ext Price

Subtotal:

Total Coupon Savings:

()

Your cart is currently empty.

- Coupon Code

I8856-01 Isocyclosporin A CAS: 59865-16-6

CAS Number

Grade

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

References

USBio References

Pricing

Order

Cart Summary

Recently Viewed

Special Offers

Contact Us

Site Map

Technical Resources

Distributors

Payment Methods