USBio Logo

L3450 Lovastatin (Mevinolin) CAS: 75330-75-5

Specifications
References
CAS Number
75330-75-5
Grade
Molecular Biology Grade
Molecular Formula
C24H36O5
Molecular Weight
404.5
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
Mevinolin; 6a-Methylcompactin; Monakolin K; MK-803, 6-alpha-Methylcompactin; BRN 3631989

Cancer cell line apoptotic inducer via HMG-CoA reductase mechanism. Statin compound. Potent competitive HMG-CoA reductase inhibitor. Anti-hypercholesterolemic agent. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. Inhibits the isoprenylation of Ras and Rho family GTPases. Causes cell cycle arrest in G1 and G2/M phases through modulation of proteasome in cancer cell lines. Smooth muscle cell proliferation inhibitor. Apoptosis inducer. Anticancer compound. Anti-adhesive, immunomodulatory and anti-inflammatory compound. Stimulates bone formation. Increases cellular resistance to anticancer agents such as doxorubicin and etoposide. Suppresses ICAM-1-LFA-1 interactions, which blocks virus replication and infection. Anti-hypertensive agent. Suppresses TNF-induced NF-kappaB activation. Modulates key cell signaling pathways, like Ras, MAPK and EGFR (modest).

Synonyms
Mevinolin; 6a-Methylcompactin; Monakolin K; MK-803, 6-alpha-Methylcompactin; BRN 3631989
Source
Aspergillus sp.
CAS Number
75330-75-5
Molecular Formula
C24H36O5
Molecular Weight
404.5
Purity
≥98.5%
Appearance
White crystalline powder
Solubility
Soluble in DMSO and ethanol
Loss on Drying
≤0.1%
Heavy Metals
≤0.002%
Specific Rotation
+324°-338°
Residue on Ignition
≤0.2%
Indentification (Infrared, UV)
Conforms to reference
Exceeds USP Specifications
Important Note
Toxicity and Hazards
 
References
1. Ghosh, P.M., et al., Biochim. Biophys. Acta 1359: 13 (1997). 2. Keyomarsi, K. et al. Cancer Research 51: 3602 (1991) Activation reference
USBio References
No references available
Pricing
Order
Proceed to Checkout
Cart Summary
ProductSizeListYour PriceQtyExt Price
Subtotal:Subtotal:
Subtotal:Subtotal:
Total Coupon Savings:Total Coupon Savings:()
Your cart is currently empty.
- Coupon Code
Recently Viewed
  • Contact Us

    Visit our technical library or contact our support staff to answer your questions.

    Telephone:
    1-800-520-3011

    Library | Contact

    Distributors

    For customers outside of the United States, please use one of our many distributors.

    View Distributors

    Payment Methods

    We accept the following payment methods as well as pay-by-invoice.

    MasterCard Visa PayPal
    © 2023-2024 United States Biological - All Rights Reserved